在本文中，我们为Pavlovian信号传达的多方面的研究 - 一个过程中学到的一个过程，一个代理商通过另一个代理商通知决策的时间扩展预测。信令紧密连接到时间和时间。在生成和接收信号的服务中，已知人类和其他动物代表时间，确定自过去事件以来的时间，预测到未来刺激的时间，并且都识别和生成展开时间的模式。我们调查通过引入部分可观察到的决策域来对学习代理之间的影响和信令在我们称之为霜冻空心的情况下如何影响学习代理之间的影响和信令。在该域中，预测学习代理和加强学习代理被耦合到两部分决策系统，该系统可以在避免时间条件危险时获取稀疏奖励。我们评估了两个域变型：机器代理在七态线性步行中交互，以及虚拟现实环境中的人机交互。我们的结果展示了帕夫洛维亚信号传导的学习速度，对药剂 - 代理协调具有不同时间表示（并且不）的影响，以及颞次锯齿对药剂和人毒剂相互作用的影响方式不同。作为主要贡献，我们将Pavlovian信号传导为固定信号范例与两个代理之间完全自适应通信学习之间的天然桥梁。我们进一步展示了如何从固定的信令过程计算地构建该自适应信令处理，其特征在于，通过快速的连续预测学习和对接收信号的性质的最小限制。因此，我们的结果表明了加固学习代理之间的沟通学习的可行建设者的途径。

人工智能系统越来越涉及持续学习，以实现在系统培训期间不遇到的一般情况下的灵活性。与自治系统的人类互动广泛研究，但在系统积极学习的同时，研究发生了迄今为止发生的互动，并且可以在几分钟内明显改变其行为。在这项试验研究中，我们调查如何在代理商发展能力时如何发展人类和不断学习的预测代理人之间的互动。此外，我们可以比较两个不同的代理架构来评估代理设计中的代表性选择如何影响人工代理交互。我们开发虚拟现实环境和基于时间的预测任务，其中从增强学习（RL）算法增强人类预测中学到的预测。我们评估参与者在此任务中的性能和行为如何在代理类型中不同，使用定量和定性分析。我们的研究结果表明，系统的人类信任可能受到与代理人的早期互动的影响，并且反过来的信任会影响战略行为，但试点研究的限制排除了任何结论的声明。我们将信任作为互动的关键特征，以考虑基于RL的技术在考虑基于RL的技术时，并对这项研究进行了几项建议，以准备更大规模的调查。本文的视频摘要可以在https://youtu.be/ovyjdnbqtwq找到。

Multi-agent artificial intelligence research promises a path to develop intelligent technologies that are more human-like and more human-compatible than those produced by "solipsistic" approaches, which do not consider interactions between agents. Melting Pot is a research tool developed to facilitate work on multi-agent artificial intelligence, and provides an evaluation protocol that measures generalization to novel social partners in a set of canonical test scenarios. Each scenario pairs a physical environment (a "substrate") with a reference set of co-players (a "background population"), to create a social situation with substantial interdependence between the individuals involved. For instance, some scenarios were inspired by institutional-economics-based accounts of natural resource management and public-good-provision dilemmas. Others were inspired by considerations from evolutionary biology, game theory, and artificial life. Melting Pot aims to cover a maximally diverse set of interdependencies and incentives. It includes the commonly-studied extreme cases of perfectly-competitive (zero-sum) motivations and perfectly-cooperative (shared-reward) motivations, but does not stop with them. As in real-life, a clear majority of scenarios in Melting Pot have mixed incentives. They are neither purely competitive nor purely cooperative and thus demand successful agents be able to navigate the resulting ambiguity. Here we describe Melting Pot 2.0, which revises and expands on Melting Pot. We also introduce support for scenarios with asymmetric roles, and explain how to integrate them into the evaluation protocol. This report also contains: (1) details of all substrates and scenarios; (2) a complete description of all baseline algorithms and results. Our intention is for it to serve as a reference for researchers using Melting Pot 2.0.

Although prediction models for delirium, a commonly occurring condition during general hospitalization or post-surgery, have not gained huge popularity, their algorithmic bias evaluation is crucial due to the existing association between social determinants of health and delirium risk. In this context, using MIMIC-III and another academic hospital dataset, we present some initial experimental evidence showing how sociodemographic features such as sex and race can impact the model performance across subgroups. With this work, our intent is to initiate a discussion about the intersectionality effects of old age, race and socioeconomic factors on the early-stage detection and prevention of delirium using ML.

Proteins play a central role in biology from immune recognition to brain activity. While major advances in machine learning have improved our ability to predict protein structure from sequence, determining protein function from structure remains a major challenge. Here, we introduce Holographic Convolutional Neural Network (H-CNN) for proteins, which is a physically motivated machine learning approach to model amino acid preferences in protein structures. H-CNN reflects physical interactions in a protein structure and recapitulates the functional information stored in evolutionary data. H-CNN accurately predicts the impact of mutations on protein function, including stability and binding of protein complexes. Our interpretable computational model for protein structure-function maps could guide design of novel proteins with desired function.

机器学习和临床研究社区利用现实世界数据（RWD）的方法，包括电子健康记录中捕获的数据（EHR）截然不同。虽然临床研究人员谨慎使用RWD进行临床研究，但用于医疗团队的ML会消费公共数据集，并以最少的审查来开发新算法。这项研究通过开发和验证ML-DQA来弥合这一差距，ML-DQA是基于RWD最佳实践的数据质量保证框架。 ML-DQA框架适用于两个地理位置的五个ML项目，分别是不同的医疗状况和不同的人群。在这五个项目中，共收集了247,536名患者的RWD，共有2,999项质量检查和24份质量报告。出现了五种可推广的实践：所有项目都使用类似的方法来分组冗余数据元素表示；所有项目都使用自动实用程序来构建诊断和药物数据元素；所有项目都使用了一个共同的基于规则的转换库；所有项目都使用统一的方法将数据质量检查分配给数据元素；所有项目都使用类似的临床裁决方法。包括临床医生，数据科学家和受训者在内的平均有5.8个人参与每个项目实施ML-DQA，每个项目平均进行了23.4个数据元素。这项研究证明了ML-DQA在医疗项目中的重要性作用，并为团队提供了开展这些基本活动的框架。

我们概述了新兴机会和挑战，以提高AI对科学发现的效用。AI为行业的独特目标与AI科学的目标创造了识别模式中的识别模式与来自数据的发现模式之间的紧张。如果我们解决了与域驱动的科学模型和数据驱动的AI学习机之间的“弥补差距”相关的根本挑战，那么我们预计这些AI模型可以改变假说发电，科学发现和科学过程本身。

有限的角度X射线断层扫描重建是一个不良反问题一般。特别是当投影角度有限并且在光子限制条件下进行测量时，来自经典算法的重建，例如过滤的反光，可能导致由于缺失的问题而获取伪影。为了获得令人满意的重建结果，通常在重建算法中结合在重建算法中的令人满意的重建结果，例如总变化最小化和非局部图像相似度。在这项工作中，我们介绍了深度神经网络，以确定并应用重建过程的先前分配。我们的神经网络直接从合成训练样本中学习。因此，神经网络获得了对我们对重建感兴趣的对象类的特定的先前分配。特别是，我们使用了具有3D卷积层和3D注意图层的深生成的模型，这些层在来自DubBed电路库的3D合成集成电路（IC）数据上培训。我们证明，当投影角度和光子预算受到限制时，来自我们深度生成模型的前沿可以显着提高合成数据的IC重建质量，而与最大似然估计相比。使用电路库的合成IC数据训练深度生成模型说明了从机器学习之前学到的学习功能。我们预计，如果使用实验数据再现过程，机器学习的优势将持续存在。机器学习在有限角X射线断层扫描的优点可以进一步能够在低光子纳米级成像中实现应用。

Dataset distillation has emerged as a prominent technique to improve data efficiency when training machine learning models. It encapsulates the knowledge from a large dataset into a smaller synthetic dataset. A model trained on this smaller distilled dataset can attain comparable performance to a model trained on the original training dataset. However, the existing dataset distillation techniques mainly aim at achieving the best trade-off between resource usage efficiency and model utility. The security risks stemming from them have not been explored. This study performs the first backdoor attack against the models trained on the data distilled by dataset distillation models in the image domain. Concretely, we inject triggers into the synthetic data during the distillation procedure rather than during the model training stage, where all previous attacks are performed. We propose two types of backdoor attacks, namely NAIVEATTACK and DOORPING. NAIVEATTACK simply adds triggers to the raw data at the initial distillation phase, while DOORPING iteratively updates the triggers during the entire distillation procedure. We conduct extensive evaluations on multiple datasets, architectures, and dataset distillation techniques. Empirical evaluation shows that NAIVEATTACK achieves decent attack success rate (ASR) scores in some cases, while DOORPING reaches higher ASR scores (close to 1.0) in all cases. Furthermore, we conduct a comprehensive ablation study to analyze the factors that may affect the attack performance. Finally, we evaluate multiple defense mechanisms against our backdoor attacks and show that our attacks can practically circumvent these defense mechanisms.

We present a dynamic path planning algorithm to navigate an amphibious rotor craft through a concave time-invariant obstacle field while attempting to minimize energy usage. We create a nonlinear quaternion state model that represents the rotor craft dynamics above and below the water. The 6 degree of freedom dynamics used within a layered architecture to generate motion paths for the vehicle to follow and the required control inputs. The rotor craft has a 3 dimensional map of its surroundings that is updated via limited range onboard sensor readings within the current medium (air or water). Path planning is done via PRM and D* Lite.